An integrated model for termination of RNA polymerase III transcription

J Xie, U Aiello, Y Clement, N Haidara, M Girbig… - Science …, 2022 - science.org
… Last, we also observed Sen1-dependent release of RNAPIIIs that are paused at sequences
other than T-tracts, for instance, at pausing sites upstream of the canonical terminators, …

New insights into the mechanisms of transcription termination by RNA polymerase III

J Xie - 2021 - theses.hal.science
termination of RNAPIII transcription in budding yeast. In this study, to address specifically
the function of Sen1 in RNAPIII transcription termination … Eukaryotic RNA polymerase II (RNAPII…

Senataxin homologue Sen1 is required for efficient termination of RNA polymerase III transcription

J Rivosecchi, M Larochelle, C Teste, F Grenier… - The EMBO …, 2019 - embopress.org
transcription termination at a subset of RNA polymerase II genes. Whether Senataxin also
contributes to transcription termination at … efficient Sen1-dependent transcription termination

Elongating RNA polymerase II and RNA: DNA hybrids hinder fork progression and gene expression at sites of head-on replication-transcription collisions

L Zardoni, E Nardini, A Brambati, C Lucca… - Nucleic Acids …, 2021 - academic.oup.com
… As shown in Figure 6D, H3K4me2 levels decreased in HU-treated sen1 URL mutants
relative to WT, while the inactivation of Spt2 partially rescued such sen1-dependent defect. …

Mechanisms of eukaryotic transcription termination at a glance

J Xie, D Libri, O Porrua - Journal of cell science, 2023 - journals.biologists.com
Transcription termination occurs when the RNA polymerase (… Efficient transcription termination
is crucial not only for the … of transcription termination factors with the RNA polymerase II

[PDF][PDF] RNA polymerase II CTD tyrosine 1 is required for efficient termination by the Nrd1-Nab3-Sen1 pathway

P Collin, C Jeronimo, C Poitras, F Robert - Molecular cell, 2019 - cell.com
Transcription by RNA polymerase II involves the CTD of its largest subunit, but the role of
this … 0 end of genes and that this pause promotes termination of small non-coding RNAs. …

Termination of non‐coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD‐mimicking region in Sen1

Z Han, O Jasnovidova, N Haidara, A Tudek… - The EMBO …, 2020 - embopress.org
… In addition, we show that Sen1-dependent termination strictly requires CTD recognition by …
action in the context of a kinetic competition between termination and elongation. We also find …

[HTML][HTML] Single-molecule characterization of extrinsic transcription termination by Sen1 helicase

S Wang, Z Han, D Libri, O Porrua, TR Strick - Nature Communications, 2019 - nature.com
… statistical and kinetic analysis of Pol II interactions with a … the kinetics of extrinsic eukaryotic
transcription termination … cerevisiae RNA Polymerase II (Pol II) was purified from a strain that …

[PDF][PDF] Sen1 is a key regulator of transcription-driven conflicts

U Aiello, D Challal, G Wentzinger, A Lengronne… - Molecular Cell, 2022 - cell.com
RNA polymerase II at TRCs within genes and the rDNA and at sites of transcription-transcription
We therefore first analyzed Sen1-dependent alterations on RNAPII distribution focusing …

Single-molecule characterization of Sen1 translocation properties provides insights into eukaryotic factor-dependent transcription termination

S Wang, Z Han, TR Strick - Nucleic Acids Research, 2024 - academic.oup.com
RNA polymerase II (Pol II) complex. We quantify Sen1 translocation activity on single-stranded …
with kinetic competition models for Sen1-dependent termination of transcribing Pol II (6). …